Towards knowledge-based design of pharmaceutical crystal forms

Desirability-based architectural design of forms

Abstract The decisions and personal preferences of the designer are vital for all aspects and stages of the design. To elaborate, the designer has the central role in creation, development, detailing and construction of the built forms. Also, the scientific/engineering evaluations of the design models are carried out under the directions and decisions of the designer. The paper explores the con...

Knowledge-based approaches to crystal design{

The 365 000 crystal structures recorded so far in the Cambridge Structural Database (CSD) have already been used extensively in the study of intermolecular interactions and crystal packing, providing fundamental knowledge that can be applied in crystal engineering and crystal design. However, as the scientific problems posed to the CSD become more sophisticated, there is a need to develop more ...

Novel Challenges in Crystal Engineering: Polymorphs and New Crystal Forms of Active Pharmaceutical Ingredients

desirability-based architectural design of forms

abstract the decisions and personal preferences of the designer are vital for all aspects and stages of the design. to elaborate, the designer has the central role in creation, development, detailing and construction of the built forms. also, the scientific/engineering evaluations of the design models are carried out under the directions and decisions of the designer. the paper explores the con...

Forms of Discovery for Design Knowledge

The article at hand analyses an often disregarded aspect of design science research that is how design knowledge is actually built or, more precisely, how new design knowledge is discovered. In the article we distinguish abductive and inductive forms of discovery. We describe how inductive and abductive discoveries are dealt with in traditional science and how these two forms of discovery have ...